Public Health Seminar Series:

Inexpensive, Point-of-Care, Molecular Diagnostics for Infectious Diseases by Changchun Liu, PhD

Monday, September 28, 2015 12:00pm - 1:00pm Calit2 Auditorium OCW Video Archive
Seminar Abstract

Rapid and timely diagnosis of infectious diseases at the point-of-care is critical for prompt and appropriate therapeutic intervention. There is an urgent need for inexpensive, point-of-care, molecular diagnostic systems in low and middle-income countries due to lack of testing facilities, shortage of trained personnel, and severe cost constraints. In this talk, I will present our work towards the development of inexpensive, microfluidic-based systems for infectious disease diagnostics and therapy monitoring such as HIV viral load testing. The main focus of my talk will be on: 1) Disposable plasma separators for relatively large-volume plasma separation without a need for any centrifugation; 2) a ‘nuclemeter’ lab-on-chip device based on a reaction-diffusion mode amplification and fluorescent detection for simplified endpoint quantitative detection; and 3) Smart cup for non-instrumented, smartphone-based molecular diagnostics. These devices are suitable for use at home, in the field, and in poor-resource settings, where access to sophisticated laboratories is impractical, unaffordable, or nonexistent.

Speaker Biography - Changchun Liu, PhD

Changchun Liu, PhD
Changchun Liu, PhD Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania
Dr. Changchun Liu is a research assistant professor at the University of Pennsylvania School of Engineering and Applied Science. He received his PhD degree in Electronics Engineering from the Institute of Electronics, Chinese Academy of Sciences (IECAS), Beijing, China. Dr. Liu's research interests include microfluidics, BioMEMS (Biomedical MicroElectroMechanical Systems), biosensors, point-of-care (POC) diagnostics, and micro/nano fabrication technology. He is a recipient of an NIH Career Development Award (K25).

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