Diseases like malaria and dengue virus are transmitted by mosquito and are responsible for millions of cases and hundreds of thousands of deaths in the world in each year. In order to understand what treatments work and how to develop vaccines for these diseases, research must be translated from the laboratory bench and animal models to clinical trials in the US, and ultimately to endemic countries overseas. In today’s world where many mosquito-borne diseases are responsible for unexpected and explosive outbreaks, innovative approaches are required in order to curb these epidemics. As the Laboratory of Malaria and Vector Research, we are focused on to understanding vector-host interactions in order to develop and advance novel strategies like saliva-based vaccines. In conjunction with our local partners, our NIAID laboratory and field sites in Cambodia afford the opportunity to investigate the immunologic relationships of the vector-host-pathogen triad. This talk will provide an overview of multidrug-resistant malaria and dengue in Cambodia and how operational and translational research approaches are used to combat these disease threats in the Greater Mekong Subregion.
Speaker Biography - Dr. Jessica Manning, M.D., M.S.
Dr. Jessica Manning, M.D., M.S.
National Institute of Allergy and Infectious Diseases (NIAID), Washington, DC & Cambodian National Center for Parasitology, Entomology and Malaria Control, Phnom Penh
Dr. Jessica Manning is an infectious diseases physician-scientist, currently based in Phnom Penh as part of a research collaboration between the Cambodian National Center for Parasitology, Entomology, and Malaria Control and the US National Institute of Allergy and Infectious Diseases in Washington, DC. She received her undergraduate degree in Genetics from University of Georgia Honors Program and a graduate biomedical sciences diploma in Immunology from Victoria University of Wellington, New Zealand. She received her medical degree from Emory University School of Medicine in Atlanta, Georgia. In 2008, she moved to Mali to run a severe malaria case-control study as a Fogarty International Clinical Research Scholar at the Malaria Research and Training Center in Bamako. From 2010 to 2014, as a clinical fellow at Harvard Medical School, she completed the Doris and Howard Hiatt Residency in Global Health Equity and Internal Medicine at Brigham and Women’s Hospital and received her Master of Science in Epidemiology at the Harvard TH Chan School of Public Health. While in Boston, she was affiliated with the non-governmental organization Partners in Health and worked as a physician at their partner hospitals in Rwanda and Malawi. From 2013 to 2015, she lived in Bangkok, Thailand as a research physician at the Armed Forces Research Institute of Medical Sciences and focused on clinical trials related to multidrug-resistant malaria and its elimination in the Greater Mekong Subregion. Afterwards, she completed her clinical infectious diseases fellowship at the National Institute of Allergy and Infectious Diseases (NIAID). In 2017, she re-located to Cambodia to serve as an attaché to the US Embassy in order to further NIAID’s mission of conducting international translational and clinical research related to vector-borne diseases and other emerging threats.
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