Chronic inflammation is believed to result from a sustained response to immune homeostasis disruption. Immune homeostasis in the intestines is maintained through epithelial, innate, and adaptive immune cell defense mechanisms that involve pattern recognition receptors (PRRs). Toll-like receptors (TLRs) and receptors for advanced glycation end products (RAGE, HUGO nomenclature AGER) are part of host PRRs that recognize endogenous (such as bacterial components) and exogenous (such as dietary nutrients) ligands. The ligation of TLRs and AGER with ligands can trigger NF-kB activation, resulting in inflammatory response. The presentation will summarize our current research on receptor for advanced glycation end products and colorectal and pancreatic cancer as well as TLR, gut microbiome and risk of advanced colorectal adenoma.
Speaker Biography - Li Jiao, M.D., M.S., Ph.D.
Li Jiao, M.D., M.S., Ph.D.
Baylor College of Medicine, Dan L. Duncan Comprehensive Cancer Center, Houston, Texas
Dr. Li Jiao is a Tenured Associate Professor of Medicine at Baylor College of Medicine. She is a molecular epidemiologist with the academic background of environment medicine. She earned a medical degree and master’s degree in China. She earned the PhD degree at UT- M.D. Anderson Cancer Center and had postdoc training at the National Cancer Institute. Her broad research goals are to identify genetic and modifiable environmental risk factors for gastrointestinal cancers as well as to search for intermediate biomarkers of environmental exposure and to identify new targets for pharmaceutical or behavioral interventions for cancer prevention. With the support from the NIH National Cancer Institute and Cancer Prevention Research Institute of Texas, she is currently investigating the relationship between human gut microbiome, diet, and colorectal adenoma in a hospital-based study. She also investigates dietary contribution to chronic inflammation and cancer. She pioneers the research on advanced glycation end-products and pancreatic cancer.
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