Public Health Seminar Series:

Obesity and Gastrointestinal Cancers: Evidence, Debates and Implications by Yunxia Lu, M.D., M.Sc., Ph.D.

Monday, November 9, 2015 12:00 PM - 1:00 PM Calit2 Auditorium OCW Video Archive
Seminar Abstract

Growing evidence shows that obesity plays an important role on changing incidence pattern of gastrointestinal (GI) cancers during the past decades. Based on epidemiological and clinical evidence, we have investigated whether phenotypes of obesity, obesity related biomarkers, nutrients or diet patterns were associated with risk of GI cancers. Several obesity-related pathways have been hypothesized. Obesity-driven chronic inflammation, that involves rather diverse components such as innate immunity, adipocytokines, insulin, insulin-like growth factors and the gut microbiota, has been regarded as the crucial contributing factor. This inflammation might be mitigated by dietary phytochemicals. However, surgical procedures including anti-reflux surgery and bariatric surgery might not be able to stop the progression of GI cancers. Further work tries to elucidate in more details of underlying mechanisms in the development of obesity-related GI cancer and the targets of breaking the obesity-GI cancer link.

Speaker Biography - Yunxia Lu, M.D., M.Sc., Ph.D.

Yunxia Lu, M.D., M.Sc., Ph.D.
Yunxia Lu, M.D., M.Sc., Ph.D. Dept. of Molecular Medicine & Surgery, Karolinska Institute, Sweden; and School of Public Health, Imperial College, London
Dr. Lu is a Senior Researcher in Epidemiology at the Karolinska Institute in Stockholm, Sweden. She also holds an appointment as a Researcher in Biostatistics and Epidemiology at Imperial College, London, England, where she served as a Marie Curie Fellow. Dr. Lu's research focuses on the epidemiology, etiology, prevention, and treatment of gastrointestinal (GI) disorders. She has several years of experience with Nordic health registery-based research, patient-oriented research, clinical trials, clinical follow up studies,and population-based research.

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